Job Description

About the Role  

 We are looking for a hands-on, team-oriented Scientist I to support protein science efforts to develop molecular glue therapies to target previously undruggable proteins. At Neomorph, we combine biology, chemistry, and the molecular sciences in a collaborative, fast-moving environment to translate bold ideas into transformative medicines. This role will focus on biochemical experimentation to enable targeted protein degradation programs from early discovery through preclinical development.

What You’ll Do

• Purify recombinant E3 ligases and disease relevant proteins for biochemical studies.
• Develop, optimize, and execute biochemical and cell-based assays for ligand identification, lead discovery, and structure activity relationship studies.
• Analyze experimental data and clearly communicate results to project teams.
• Work closely with biologists and chemists to advance shared project goals.
• Maintain clear, reproducible experimental records and contribute to a culture of scientific rigor.
• Develop new techniques and advances in protein science and targeted protein degradation.

Required Qualifications:

• Ph.D. in Biochemistry or related field with 0–2 years of experience, MS with 5+ years of relevant industry experience or BS with 10+ years of relevant industry experience.
• Strong hands-on experience in protein expression and purification.
• Proven proficiency with AKTA FPLC systems.
• Experience with large protein complexes for biochemical characterization.
• Proficiency in standard cell and tissue culture techniques.
• Apply various assay formats, including protein-ligand and protein-protein interaction techniques (such as HTRF, DSF, AlphaScreen, among others).
• Highly collaborative mindset with the ability to work effectively in cross-functional teams.
• Comfortable operating in a dynamic, evolving biotech environment with shifting priorities.
• Strong attention to detail, ownership of work, and enthusiasm for learning.

Preferred Qualifications:

• Experience in the protein degradation field is a plus

What we offer:  

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well  

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard) 

Have Fun!  

We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us:  

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. 

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

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